Novel non-obturation based concept of regeneration

Apical debris extrusion

Submitted: 15 May 2024
Accepted: 23 May 2024
Published: 14 June 2024
Abstract Views: 90
PDF: 34
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Aim: This systematic review aimed to evaluate the healing achieved through a novel SealBio technique and assess the inherent complications or failures caused during treatment of endodontic diseases.

Methodology: The present review was conducted according to the PRISMA guidelines and was registered in PROSPERO (Registration number – CRD42020201943). The research question was formulated based on the PICO strategy. A comprehensive electronic literature search was conducted across PubMed/Medline, Google Scholar and Cochrane Database independently by two reviewers. Articles published on SealBio up to May 2024 were included. Based on the specified inclusion and exclusion criteria, the selected articles were subjected to quality assessment, and the risk of bias was conducted using the Cochrane risk of the bias assessment tool.

Results: A total of 4 studies were included in the present systematic review and reported success rates with the SealBio technique around 97-100%. However, all included papers demonstrated a high overall risk of bias and some limitations.

Conclusion: Based on the present study, SealBio technique did not furnished concrete evidence to replace the standard endodontic protocol. However, additional evidences provided by standardized and well conducted clinical trials with low risk of bias are needed.

Supporting Agencies


Teja, K. V., Mustafa, M., Esposito, L., Iaculli, F., & Cernera, M. (2024). Novel non-obturation based concept of regeneration: Apical debris extrusion. Giornale Italiano Di Endodonzia, 38(2).


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