Postoperative Pain Following Endodontic Treatment in Patients

Submitted: 15 April 2025
Accepted: 22 May 2025
Published: 9 June 2025
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Aim: Diabetic patients may exhibit altered responses to nerve stimulation due to diabetes-related neurological damage. This prospective, non-randomized, parallel, blinded clinical trial evaluated postoperative pain following endodontic treatment by comparing two groups of patients—with and without type 2 diabetes mellitus (T2DM).

Methodology: Eighty adult patients were included: 40 with T2DM and 40 without T2DM. At baseline, glycated hemoglobin (HbA1c) levels were recorded. Endodontic treatment was performed and root canals were irrigated with 2.5% sodium hypochlorite solution. Postoperative pain was assessed by a blinded researcher at 6, 12, 24, and 72 hours using a Numerical Rating Scale (NRS, 0–10).

Results: Within the first 6 hours, 19 patients in the T2DM group and 24 in the control group reported pain (p = 0.429). After 12 hours, 11 T2DM patients and 19 control patients experienced pain (p = 0.165). At 24 hours, 9 patients with T2DM and 11 in the control group reported pain (p = 0.930). After 72 hours, 5 patients from each group reported pain (p = 0.186). No significant differences in pain intensity were observed between the groups at 6 hours (p = 0.139), 12 hours (p = 0.169), 24 hours (p = 0.387), or 72 hours (p = 0.687). However, regression analysis revealed that patients with T2DM had lower odds of experiencing postoperative pain (OR = 0.19; 95% CI = 0.04–0.77), regardless of sex, age, preoperative pain, tooth type, treatment modality, or sealer extrusion.

Conclusions: Patients with T2DM may experience less postoperative pain following endodontic treatment.

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Supporting Agencies

Brazilian National Council for Scientific and Technological Development

How to Cite

Cunha, I. L. M., Martins, I. E. B., de Oliveira, J. W. C., Hanan, S. A., Herkrath, F. J., & Sponchiado Júnior, E. C. (2025). Postoperative Pain Following Endodontic Treatment in Patients . Giornale Italiano Di Endodonzia, 35. https://doi.org/10.32067/GIE.2025.518