Dentinal tubule penetration of bioceramic-based versus epoxy resin-based root canal sealers: a systematic review and meta-analysis
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Accepted: 26 May 2022
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An ideal endodontic treatment involves filling the root canal system with a sealer that penetrates the dentinal tubules and remains intact. Hence, this systematic review aimed to appraise and analyse the dentinal tubule penetration of bioceramic-based and epoxy resin-based root canal sealers.
Articles published between January 1990 and March 2022 were searched in seven online databases (Google Scholar, PubMed, Web of Science – Core collection, Scopus, Cochrane Library, EBSCO, and Open Grey). Only in-vitro studies evaluating dentinal tubule penetration of bioceramic-based and epoxy resin-based sealers were selected. The OHAT risk of bias (RoB) tool was employed to analyse the RoB of each article. A two-arm meta-analysis based on the DerSimonian-Laird random-effects model was used to assess the standardised weighted mean differences in dentinal tubule penetration for both sealer types.
Although bioceramic-based root canal sealers exhibit inferior dentinal tubule penetration than epoxy resin-based sealers, future well-designed studies with standardised evaluation tools and a more control of confounding variables should be conducted.
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