Effects of mineral trioxide aggregate and platelet-rich fibrin on histological results of direct pulp capping in dogs


Submitted: 3 June 2020
Accepted: 5 October 2020
Published: 14 January 2021
Abstract Views: 1217
PDF: 523
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Aim: This study aimed to compare the effects of mineral trioxide aggregate (MTA) and platelet-rich fibrin (PRF) on histological results of direct pulp capping (DPC) in dogs.

Methodology: In this animal study, 36 class V cavities were prepared in the incisors of adult healthy mixed-breed dogs. The teeth were then randomly divided into three groups. No material was placed in the control teeth. MTA and PRF were placed on the exposure site in groups 2 and 3, respectively. After 2 months, the teeth were extracted under general anesthesia and were histological analyzed regarding inflammation, calcified bridge formation and necrosis. Data were analyzed using non-parametric Kruskal-Wallis test. Pairwise comparisons were made using the Mann-Whitney U test.

Results: There are no statistically significant differences in terms of pulp inflammation, dentinal bridge formation and necrosis among the treatment groups capping with MTA and PRF. (P Value >0.05), however, PRF and MTA were the same in all parameters, these groups were both significantly superior to the control group.

Conclusion: Within the limitations of this study, PRF can be used for DPC as an alternative to MTA.


Aghamohammadi Ameghani, B. ., Tavakoli, A., Hasani Tabatabaei, M., & Valizadeh, S. (2021). Effects of mineral trioxide aggregate and platelet-rich fibrin on histological results of direct pulp capping in dogs. Giornale Italiano Di Endodonzia, 35(1). https://doi.org/10.32067/GIE.2021.35.01.01

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