Triple antibiotic paste versus nano calcium hydroxide as an intracanal medicament in human primary molars: a randomized clinical trial


Submitted: 17 July 2023
Accepted: 19 September 2023
Published: 17 October 2023
Abstract Views: 183
PDF: 61
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Authors

  • Ahmad Gholami Biotechnology Research Center and Department of Pharmaceutical Biotechnology, School of Pharmacy and Department of Medical Nanotechnology, School of Advanced Medical Science and Technology, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of. https://orcid.org/0000-0003-1851-159X
  • Khatereh Asadi Biotechnology Research Center and Department of Medical Nanotechnology, School of Advanced Medical Science and Technology, Shiraz University of Medical Sciences, Shiraz and Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran, Islamic Republic of. https://orcid.org/0000-0002-0781-2410
  • Nazaffarin Samiraninezhad Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of. https://orcid.org/0000-0002-4224-5247
  • Dordaneh Ghaffaripour Department of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
  • Azam Safari Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz , Iran, Islamic Republic of.
  • Yasamin Ghahramani Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
  • Abbas Abbaszadegan Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.

Aim: Intracanal medicaments play a critical role in cleaning microbial biofilm, dentin tubule sterilization, and successful endodontic treatment. This study aimed to evaluate the antibacterial effect of Nano-calcium hydroxide (NCH) and Triple Antibiotic Paste (TAP) as intra-canal medicaments in human non-vital primary molar teeth.

Methodology: The NCH particles were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). This study included 39 primary molar teeth with an indication for non-vital pulp therapy. Following the access cavity preparation, a microbial sample (S1) of each tooth was collected and canals were prepared by chemo-mechanical technique. Using dynamic block randomization, canals were divided into three groups based on the type of medicament. The second microbial sample (S2) was collected 7 days after ICM application. The canal's aerobic and anaerobic micro-organisms load was calculated by counting colony-forming units (CFUs).

Results: The TEM, FTIR, and XRD characterization techniques confirm the NCH nanoparticle formation. NCH showed a reduction of the number of aerobic and anaerobic micro-organisms by 98.09% and 90.79%, respectively. While TAP had greater antibacterial activity compared to NCH aerobic (99.95%) and anaerobic (99.78%) micro-organisms. NCH and TAP showed a statistically significant difference (P<0.005) in bacterial elimination of the root canals in comparison with chemo-mechanical irrigation alone.

Conclusion: Both TAP and NCH antibacterial activity were approved during the endodontic.


Gholami, A., Asadi, K., Samiraninezhad, N., Ghaffaripour, D., Safari, A., Ghahramani, Y., & Abbaszadegan, A. (2023). Triple antibiotic paste versus nano calcium hydroxide as an intracanal medicament in human primary molars: a randomized clinical trial. Giornale Italiano Di Endodonzia, 37(2). https://doi.org/10.32067/GIE.2023.37.01.22

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