Histological and histochemical aspects of the dentin-pulp complex in offsprings of rats treated with fluoxetine during pregnancy and lactation
Accepted: 28 July 2020
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Aim:This study aimed to analyze histological aspects of the dentin-pulp complex in rats neonates treated with fluoxetine during pregnancy and lactation.
Methodology: For this purpose were used first molars of 24 Wistar rat pups, 25 days old-aged, divided into 4 groups: PCG and PCGL whose mothers positive controls received 0.9% NaCl (oral) during gestation and gestacion/lactation, respectively; FG and FGL both mothers received fluoxetine at 20 mg / kg (oral) during pregnancy and gestation/lactation, respectively. The animals were anesthetized, maxillaries removed and fixed in 4% formaldehyde, decalcified in EDTA and processed conventionally for light microscopy. Paraffin sections were stained by Hematoxylin and Eosin, Masson’s Trichromatic and Pricosirius Red.
Results: There was no evidence of structural and histochemical changes in the pulp-dentin complex in the groups studied.
Conclusions: Therefore, we could conclude that the fluoxetine in 20 mg/kg dosage, administrated during pregnancy and lactation, did not interfered in the dentin-pulp complex development in offsprings of rats when analyzed in the age of 25 days.
Giornale Italiano di Endodonzia has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.